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uPA Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 17968-1-AP-20UL
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Description
This gene encodes a serine protease involved in degradation of the extracellular matrix and possibly tumor cell migration and proliferation. A specific polymorphism in this gene may be associated with late-onset Alzheimer′s disease and also with decreased affinity for fibrin-binding. This protein converts plasminogen to plasmin by specific cleavage of an Arg-Val bond in plasminogen. Plasmin in turn cleaves this protein at a Lys-Ile bond to form a two-chain derivative in which a single disulfide bond connects the amino-terminal A-chain to the catalytically active, carboxy-terminal B-chain. This two-chain derivative is also called HMW-uPA (high molecular weight uPA). HMW-uPA can be further processed into LMW-uPA (low molecular weight uPA) by cleavage of chain A into a short chain A (A1) and an amino-terminal fragment. LMW-uPA is proteolytically active but does not bind to the uPA receptor. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Spécification
uPA | |
Polyclonal | |
Unconjugated | |
PLAU | |
ATF, PLAU, U plasminogen activator, uPA, URK | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
18792, 25619, 5328 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot, Immunofluorescence, Immunocytochemistry, Immunoprecipitation | |
0.29 mg/mL | |
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3 | |
P00749, P06869, P29598 | |
Plau | |
uPA Fusion Protein Ag11813 | |
20 μL | |
Primary | |
Human, Mouse, Rat | |
Antibody | |
IgG |
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