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SSTR3 Rabbit anti-Human, Polyclonal, Proteintech
Rabbit Polyclonal Antibody
Marque: Proteintech 20696-1-AP-150UL
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Description
Expression of Somatostatin Receptor Type 3 (SSTR3) has been reported in brain, breast, eye, gastrointestinal tract, pancreas, and thyroid. G-protein Coupled Receptors (GPCRs) comprise one of the largest families of signaling molecules with more than a thousand members currently predicted to exist. All GPCRs share a structural motif consisting of seven membrane-spanning helices, and exist in both active and inactive forms. An array of activating ligands participate in the conformation of GPCRs which leads to signaling via G-proteins and downstream effectors. Ongoing studies have also shown the vast series of reactions which participate in the negative regulation of GPCRs. This "turn-off" activity has tremendous implications for the physiological action of the cell, and continues to drive pharmacological research for new drug candidates. Two blockbuster drugs which have been developed as GPCR-targeted pharmaceuticals are Zyprexa (Eli Lilly) and Claritin (Schering-Plough) which have multi-billion dollar shares of the mental health and allergy markets, respectively.Spécification
SSTR3 | |
Polyclonal | |
Unconjugated | |
SSTR3 | |
somatostatin receptor 3, Somatostatin receptor type 3, SS 3 R, SS3 R, SS3R, SSR 28, SSTR3 | |
Rabbit | |
Antigen Affinity Chromatography | |
RUO | |
6753 | |
-20°C | |
Liquid |
Immunohistochemistry (Paraffin), Western Blot | |
0.23 mg/mL | |
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3 | |
P32745 | |
SSTR3 | |
Peptide | |
150 μL | |
Primary | |
Human | |
Antibody | |
IgG |
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