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Invitrogen™ WDR41 Polyclonal Antibody
Rabbit Polyclonal Antibody
Marque: Invitrogen™ PA524352
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Description
WDR41 Polyclonal Antibody for Western Blot, IHC (P)
Non-catalytic component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. The C9orf72-SMCR8 complex promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. As part of the C9orf72-SMCR8 complex, stimulates RAB8A and RAB11A GTPase activity in vitro, however WDR42 is shown not be an essential complex component for this function. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ULK1/ATG1 kinase complex and inhibiting its protein kinase activity.
Spécification
| WDR41 | |
| Polyclonal | |
| Unconjugated | |
| WDR41 | |
| B830029I03Rik; MSTP048; WD repeat domain 41; WD repeat-containing protein 41; WDR41 | |
| Rabbit | |
| Antigen Affinity Chromatography, Protein A | |
| RUO | |
| 218460, 55255 | |
| Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. | |
| Liquid |
| Immunohistochemistry (Paraffin), Western Blot | |
| 0.5 mg/mL | |
| PBS with 0.09% sodium azide; pH 7.4 | |
| Q3UDP0, Q9HAD4 | |
| WDR41 | |
| KLH conjugated synthetic peptide between 249-277 amino acids from the C-terminal region of human WDR41. | |
| 400 μL | |
| Primary | |
| Human, Mouse | |
| Antibody | |
| IgG |
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