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ALAS1 Rabbit anti-Human, Mouse, Rat, Polyclonal, Proteintech

Rabbit Polyclonal Antibody

Marque:  Proteintech 16200-1-AP-20UL

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Code produit. 16815744

  • 145.00€ / 20µL

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Description

Description

ALAS-1 is a nuclear-encoded mitochondrial matrix enzyme which catalyzes the condensation of glycine with succinyl-CoA to form delta-amino levulinate, CO2 and CoA. It regulates the first and rate-limiting step of heme biosynthetic pathway. It is one of the two isoforms of ALAS and is a pyridoxal-5′ phosphate dependant housekeeping enzyme. It is ubiquitously expressed and is responsible of providing heme for cytochromes and other hemoproteins. ALAS1 in liver undergoes negative feedback regulation by heme. Transcription of ALAS1 gene is stimulated by cAMP and respiratory uncoupling whereas Phorbol esters and insulin repress ALAS1 gene expression. ALAS1 is suggested to be involved in reciprocal regulation of Heme biosynthesis and circadian clock suggesting a potential target for treatment of circadian disorders. ALAS1 gene expression is down regulated in Acute Liver failure resulting in altered heme metabolism and liver function.
Spécification

Spécification

ALAS1
Polyclonal
Unconjugated
ALAS1
ALAS, ALAS H, ALAS1, ALAS3, ALASH, Delta ALA synthase 1, MIG4
Rabbit
Antigen Affinity Chromatography
RUO
11655, 211, 65155
-20°C
Liquid
Immunofluorescence, Immunocytochemistry, Western Blot, Immunoprecipitation
0.27 mg/mL
PBS with 50% glycerol and 0.1% sodium azide; pH 7.3
P13195, P13196, Q8VC19
Alas1
ALAS1 Fusion Protein Ag9126
20 μL
Primary
Mouse, Rat, Human
Antibody
IgG
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