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Invitrogen™ Human Progesterone Receptor, Ligand Binding Domain, GST Tag Recombinant Protein

Code produit. 15430420
0.6 mg, 600µg
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Quantité:
0.6 mg
Conditionnement:
600µg
Les retours ne sont pas autorisés pour ce produit. Afficher la politique du retour.
Les retours ne sont pas autorisés pour ce produit. Afficher la politique du retour.

Recombinant Protein

Progesterone receptor ligand binding domain (PR-LBD) is a 59.83 kDa recombinant human protein (amino acids 675-933) expressed as a glutathione-S-transferase (GST) fusion protein in baculovirus-infected insect cells. PR is expressed and purified in the absence of exogenous ligands, making it ideal for ligand binding and coregulator displacement studies. PR-LBD human recombinant protein is: , Flexible—use in your in-house assay or as part of our PolarScreen™ Competitor assays for a complete assay solution, Ready to use—active and tagged (with GST), Convenient—available in bulk sizes Contact us for bulk quantities or for assistance with other nuclear receptor assay needs, from assay development to library screening and beyond. Used in:PolarScreen™ Progesterone Receptor Competitor Assay, RedPolarScreen™ Progesterone Receptor Competitor Assay, Green, Protein Form: Ligand Binding Domain, Recombinant

The progesterone receptor (PR) is a member of the steroid family of nuclear receptors. The PR mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. PR is found as a 94 kDa protein (Form A) or a 120 kDa protein (Form B) due to the use of alternative translation initiation sites. PR-B is the transcriptionally active form and is responsible for activating genes for the maintenance of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription. A Null mutation in the PGR gene leads to pleiotrophic reproductive abnormalities.
TRUSTED_SUSTAINABILITY

Spécification

Numéro d’adhésion P06401
Concentration See Label
À utiliser avec (application) Kinase Assay
Formule proprietary buffer with no preservative
Identification génétique (Entrez) 5241
Nom Human Progesterone Receptor, Ligand Binding Domain, GST Tag
Quantité 0.6 mg
Alias de gène 9930019P03Rik; BB114106; ENSMUSG00000074510; LOW QUALITY PROTEIN: progesterone receptor; NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PGR; pot. alt. progesterone receptor; putative; PR; PR-A; PR-B; Progesterone receptor; progesterone receptor A; progesterone-receptor; putative form B; steroid hormone receptor; testicular progesterone receptor; unnamed protein product
Nom usuel Progesterone Receptor
Symbole de gène(s) PGR
Longueur des protéines 675-933
Conjugué Unconjugated
Espèces Human
Recombinant Recombinant
Marqueur de protéine GST-tag
Contenu et stockage -80°C, Avoid Freeze/Thaw Cycles
Système d’expression Baculovirus
Famille de protéines Growth Factors & Receptors
Forme protéique Ligand Binding Domain, Recombinant
Forme Liquid
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Invitrogen™ Human Progesterone Receptor, Ligand Binding Domain, GST Tag Recombinant Protein >

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