Invitrogen™ PI16 Polyclonal Antibody

Description

Recommended positive controls: A549, HeLa, HepG2, HCT116. Predicted reactivity: Mouse (81%), Rat (83%), Pig (84%), Rhesus Monkey (96%), Chimpanzee (99%), Bovine (87%). IHC notes, Requires antigen retrieval using heat mediated 10mM Citrate buffer (pH6.0) or Tris-EDTA buffer (pH8.0) Store product as a concentrated solution. Centrifuge briefly prior to opening the vial.

The PI16 gene encodes the protein peptidase inhibitor 16, which is a member of the protease inhibitor family and plays roles in modulating protease activity within tissues. PI16 is primarily expressed in the prostate but is also found in other tissues, where it contributes to extracellular matrix organization and integrity by inhibiting serine proteases. By regulating protease activity, PI16 helps maintain tissue homeostasis and influences processes such as cell proliferation, differentiation, and migration. This protein's function is significant in preventing excessive proteolytic activity that could lead to tissue damage or contribute to pathological conditions like inflammation and cancer. Specifically, PI16's role in the prostate gland has been associated with modulating growth and repair mechanisms, providing potential implications in prostate cancer progression where protease activity is often dysregulated. Current research focuses on understanding PI16's interactions and regulatory mechanisms to explore its therapeutic potential in diseases characterized by abnormal protease activities.